Deprenyl and cognition

Lees AJ

Department of Neurology,
Middlesex Hospital, London, UK.
Acta Neurol Scand Suppl 1991; 136:91-4

ABSTRACT

Selegiline HCl, 10 mg per day has been reported to improve attention and episodic memory in Parkinson's disease and early Alzheimer's disease.  Selegiline also improves motor reaction times in Parkinson's and subjective feelings of increased vitality, euphoria and energy.  At doses of between 10 and 40 mg a day it has also been shown to improve depression particularly when psychomotor retardation is prominent and anxiety minimal.

  • Deprenyl   is an effective antidepressant
  • Deprenyl   in treatment-resistant older depressive patients
  • Deprenyl   + phenylalanine was beneficial in 90% of depression patients
  • Deprenyl   antidepressant effects are by means other than MAO-B inhibition
    Deprenyl   treated rats were much more sexually active
    Deprenyl
       enhances sexual performance and longevity in rats
    Deprenyl   may delay the deterioration of neurons during aging
  • Deprenyl   the history of deprenyl
  • Deprenyl   decreases susceptibility to Parkinson's & Alzheimer's disease
  • Deprenyl   restores IGF-1 to youthful levels
  • Deprenyl   protects the vascular endothelium from beta amyloid plaque
  • Deprenyl   reduces cocaine "high"
  • Deprenyl   prolongs animal lifespan by reducing oxidative damage to the brain
  • Deprenyl   may be useful in the treatment of cocaine dependence
  • Deprenyl   increases the life span in Fischer rats
  • Deprenyl   effects on short term memory in young and aged dogs
  • Deprenyl   maintains sexual acitivity in old rats
  • Deprenyl   and Fluoxetine (Prozac) do not interact in combination
  • Deprenyl   prolongs life in elderly dogs
  • Deprenyl   has a cardiac neuroprotective effect
  • Deprenyl   reduces oxidative stress and increases free radical elimination
  • Deprenyl   responses of forebrain neurons to deprenyl

  • Deprenyl   Parkinson's and Alzheimer's patients need 10 mg of deprenyl daily

  • Deprenyl   inhibits tumor growth in rats with mammary tumors

  • Deprenyl   slows the decline of sexual and learning performances in rats

  • Deprenyl   is ten times stronger than methamphetamine as a catecholaminergic

  • Deprenyl   shows favorable results in Tourette's syndrome and narcolepsy

  • Deprenyl   treated rats lived beyond the known maximum lifespan

  • Deprenyl   protects cells from the DNA damage

  • Deprenyl   may protect neurons from ischemic or oxidative damage

  • Deprenyl   prolongs animal lifespan by reducing oxidative damage to the brain

  • Deprenyl   effects on cocaine-induced euphoria

  • Deprenyl   effects on response to experimental cocaine administration  

  • Deprenyl   Are metabolites of deprenyl useful or harmful?

  • Deprenyl   slows the progression of Parkinson's disease

  • Deprenyl   suppresses excitotoxic damage in Parkinson's disease

  • Deprenyl   effect of deprenyl on arm movement in early Parkinson's

  • Deprenyl   effect on cognitive functions in early Parkinson's 

  • Deprenyl   prolongs the life span of Parkinsonian patients significantly

  • Deprenyl   depression in Parkinson's disease

  • Deprenyl   increases the dopamine content of the nerve terminals in Parkinson's

  • Deprenyl   improves visuo-motor control in early Parkinsonism

  • Deprenyl   management of early Parkinson's disease

  • Deprenyl   delays the onset of disability in Parkinsonian patients

  • Deprenyl   and tocopherol antioxidative therapy of Parkinsonism

  • Deprenyl   slows the death of nigral neurons in Parkinson's disease

  • Deprenyl   + levodopa treated Parkinson's patients live longer

  • Deprenyl   stimulates biosynthesis of cytokines interleukin-1 & 6

  • Deprenyl   effect of MAO-B inhibitors on MPP+ toxicity

  • Deprenyl   modulates the activity of catecholamine-sensitive neurons

  • Deprenyl   improves the performance of patients with Alzheimer's disease

  • Deprenyl   MAO-B inhibitors in the treatment of Alzheimer's disease

  • Deprenyl   in the treatment of Alzheimer's disease

  • Deprenyl   stimulates biosynthesis of cytokines interleukin-1 & 6

  • Deprenyl   and age-related decline of the striatal dopaminergic system

  • Deprenyl   increases dopamine in the striatum of primates

  • Deprenyl   use in treatment-resistant elderly depression patients

  • Deprenyl   effects during smoking and short-term abstinence