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The effects of L-deprenyl
on spatial
short term memory in young and aged dogs
Head E, Hartley J, Kameka AM, Mehta R,
Ivy GO, Ruehl WW, Milgram NW
University of Toronto,
Division of Life Sciences,
Scarborough, Ontario, Canada.
Prog Neuropsychopharmacol Biol Psychiatry 1996 Apr; 20(3):515-30
ABSTRACT
1. Young and aged dogs were tested on a spatial
memory task using a delayed non matching to sample technique. Dogs were
tested with 20, 70 and 110 second delay intervals. Animals were pretrained
to a stable level of performance prior to treatment.
2. During treatment
periods, dogs were orally administered a placebo or I-deprenyl in doses of
0.5 and 1.0 mg/kg in a repeated measures design.
3. Young dogs did not show
any significant effects of I-deprenyl, however the sample size was limited.
4. L-deprenyl administration improved spatial memory in aged dogs. 5. The
optimal dose or length of treatment time of I-deprenyl varied among
individual dogs.
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