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Effects of selegiline pretreatment
on response to experimental cocaine administration
Newton TF, Kalechstein A, Beckson M,
Bartzokis G, Bridge TP, Ling W
Department of Psychiatry and Biobehavioral Sciences,
UCLA, School of Medicine,
Los Angeles, CA 90073, USA.
Psychiatry Res 1999 Oct 11; 87(2-3):101-6
ABSTRACT
Several medications have been reported to
alter the subjective effects of experimentally administered
cocaine. We studied the effects of selegiline, a monoamine
oxidase B inhibitor, on the subjective effects of experimentally
administered cocaine in chronically cocaine-dependent subjects.
Eight subjects completed a protocol that involved repeated
administrations of cocaine before and after treatment with selegiline,
given in extended release form, 10 mg per day. Four days of
treatment with selegiline was associated with decreased self-reported
'high' and 'stimulated' feelings after cocaine administration,
measured as the area under the curve. Changes in other subjective
effects were less pronounced. Selegiline pretreatment had minimal
effects on the cardiovascular responses to cocaine administration.
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